Center for Multiple Myeloma Nanotherapy
The Washington University Center for Multiple Myeloma Nanotherapy (WU CMMN) will address overarching questions in bone malignancies, with a focus on multiple myeloma (MM). MM is a hematopoietic disease caused by terminally differentiated malignant plasma B-cells. Despite tremendous improvements in MM patient management, nearly all patients will eventually relapse and die from it. Leveraging the enormous institutional resources and support, diverse expertise in MM, the integral participation of patient advocates and industry partners, and synergistic integration of basic and clinical investigators, the WU CMMN will serve as a comprehensive center for the development of nanotechnology-based solutions for treating MM and bone metastasis. Anchored by three projects and two cores, we aim to improve MM treatment outcomes with minimal off-target toxicity by developing novel nanotherapeutics that combine unique drug delivery mechanisms with spatiotemporal treatment paradigms.
Samuel Achilefu and Gregory Lanza are the PIs/PDs of the Center. Dr. Achilefu is a pioneer in the development of molecular imaging probes and nanomaterials for imaging and treatment of cancer. He currently leads the translation of innovative imaging technologies and molecular probes from bench to bedside. Dr. Lanza is a distinguished leader in the development and translation of nanomaterials to the clinic. He has extensive experience in the practice of medicine, nanomedicine research and development, and pharmaceutical development in large industry as well as small biotechnology start-ups. Three synergistic and highly interactive interdisciplinary research projects will anchor the center. Each project is led by senior investigators with expertise in basic and translational research.
- Project 1: Preclinical and Clinical Imaging and Treatment of Multiple Myeloma with CMYC-MAX Nanoparticles
- Project 2: Spatiotemporally Controlled Light Therapy of Multiple Myeloma
- Project 3: Combination Therapy to Improve the Efficacy of Multiple Myeloma-Targeted Nanotherapeutics
- Core A: Imaging Biomarker Quanification and Standardization (IBQS)
- Core B: Data Management
- Core C: Developmental Program