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National Cancer Institute
National Cancer Institute U.S. National Institutes of Health National Cancer Institute
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Innovative Research in Cancer Nanotechnology (IRCN)

The IRCNs engage in directed, product-focused research that aims to translate cutting-edge science and technology into the next generation of diagnostic and therapeutic tools. These platforms serve as the core technologies for a wide array of specific applications that will ultimately benefit cancer patients.

IRCNs are designed to enable multi-disciplinary team research and transformative discoveries in basic and pre-clinical cancer research. The proposed individual, circumscribed research projects are expected to address major barriers and fundamental questions in cancer biology, diagnosis, prevention and treatment of the disease using innovative nanotechnology solutions. To advance such new nanotechnology discoveries, the platform projects take advantage of the collaborative environment of the Alliance network.

The awarded programs are listed below:

Imaging of nanotherapeutic drug action
Massachusetts General Hospital
Principal Investigators: Ralph Weissleder, M.D., Ph.D.

Nanoscale Metal-organic Frameworks for Light Triggered and X-ray Induced Photodynamic Therapy of Head and Neck Cancers
University of Chicago
Principal Investigators: Wenbin Lin, Ph.D., and Ralph Weichselbaum, M.D.

Optimizing RNA Nanoparticle's Size and Shape for Enhancing Cancer Targeting and Treatment
Ohio State University and University of Kentucky
Principal Investigators: Peixuan Guo, Ph.D, D.Sc., William Carson, M.D., Jianhua Yu, Ph.D., and Daniel Pack, Ph.D.

Stroma Breaking Theranostic Nanoparticles for Targeted Pancreatic Cancer Therapy
Emory University
Principal Investigator: Lily Yang, M.D., Ph.D., and Hui Mao, Ph.D.

Targeted Core Shell Nanogels for Triple Negative Breast Cancer
University of North Carolina at Chapel Hill
Principal Investigators: Alexander Kabanov, Ph.D, D.Sc., Rihe Liu, Ph.D., and Tatiana Bronich, Ph.D.

The rodent eye as a non-invasive window for understanding cancer nanotherapeutics
University of California, Davis
Principal Investigator: Kit Lam, M.D., Ph.D.

Thermoresponsive NanoVelcro CTC Purification System for Prostate Cancer Profiling
University of California, Los Angeles and Cedars-Sinai Medical Center
Principal Investigators: Hsian-Rong Tseng, Ph.D., and Edwin Posadas, M.D.

Treatment of Glioblastoma Using Chain-Like Nanoparticles
Case Western Reserve University
Principal Investigators: Efstathios Karathanasis, Ph.D.

UCLA Multifunctional Mesoporous Silica Nanoparticle Platform for Treatment of Pancreas Cancer
University of California, Los Angeles
Principal Investigators: Andre Nel, M.D., Ph.D., Timothy Donahue, M.D., Huan Meng, Ph.D., and Jeffrey Zink, Ph.D.

Mechanical Drugs: Harnessing Cancer Aggressiveness to Overcome Its Resistance
Masimo Corporation
Principal Investigators: Dmitri O. Lapotko, Ph.D., and Mien-Chie Hung, Ph.D.