Dartmouth Center of Cancer Nanotechnology Excellence
Ian Baker, D.Phil.
Keith Paulsen, Ph.D.
Core A: Nanoparticle Development, Production, and Characterization
Core Investigator: Ian Baker, D.Phil.
This Core provides novel, well-characterized, biocompatible magnetic nanoparticles that can be heated in an alternating magnetic field to destroy tumors. The use of these nanoparticles is for breast cancer and ovarian cancer treatments, but the nanoparticles can potentially be used for any type of cancer.
Core B: Toxicology, Pathology, and Biodistribution
Core Investigator: Lionel D. Lewis, M.D.
This Core is designed to provide toxicology, pathology, and pharmacokinetic biodistribution support to the Dartmouth CCNE research projects. The primary goals of the Core are to aid Project investigators in identifying and understanding the effects and pharmacokinetic distribution of the various magnetic nanoparticles (mNPs) in plasma, tumors, and normal tissues (organs) at various times following their administration.
Core C: Biostatistics, Data Analysis, and Computation
Core Investigator: Eugene Demidenko, Ph.D.
This Core is involved in all aspects of magnetic nanoparticles (mNPs) production, characterization, implementation, and treatment outcomes assessment over the entire funding period. A comprehensive biostatistical analysis of the mNP-induced hyperthermia treatment outcomes in animal studies lays the foundation for its successful translation into clinic environment.