Texas Center for Cancer Nanomedicine
University of Texas Health Science Center
David G. Gorenstein, Ph.D.
Mauro Ferrari, Ph.D.
Anil Sood, M.D.
Gabriel Lopez-Berestein, M.D.
Jennifer L. West, Ph.D.
Core A: Biomathematics
Core Investigators: Paolo Decuzzi, Ph.D., Mauro Ferrari, Ph.D., Michele Guidani and Vittorio Cristini, Ph.D.
This Core provides mathematical tools to predict the impact of nanoparticle-based therapy on tumor growth as well as statistical tools for the design of experiments and post-processing of data.
Core B: Biomolecular Targeting
Core Investigators: David Gorenstein, Ph.D., and Renata Pasqualini, Ph.D.
This Core provides the entire CCNE with sets of targeting reagents for the nanoparticles that not only include "gold standard" antibodies but novel aptamers and peptides to both endothelial, cancer and stem cells, both to specific cell surface ligands as well as the cells themselves.
Core C: Nanoengineering
Core Investigators: Mauro Ferrari, Ph.D., Xuewu Liu, Ph.D., and Ye Hu, Ph.D.
This Core manufactures and characterizes the mesoporous silica nanochips for proteomics and peptidomics, which are utilized in all CCNE for the monitoring of therapeutic and preventative efficacy, and the identification of multi-molecular signature markers for the early detection of ovarian and pancreatic cancer.