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National Cancer Institute
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Carolina Center of Cancer Nanotechnology Excellence
The University of North Carolina at Chapel Hill

Center Investigators

Joseph DeSimone, Ph.D.
Principal Investigator

 

Joel Tepper, M.D.
Principal Investigator

Projects

Project 1: PRINT Nanoparticles: "Calibration Quality" Nano-tools for Studying Particle Biodistribution

Project Investigator: Joseph M. DeSimone, Ph.D.
This Project addresses the implications of nanoparticle size, shape, surface chemistry, and modulus on uptake by various tissues in the body. This question can effectively be answered by the UNC-developed PRINT technology, which features exquisite control over particle properties and will result in the establishment of BioMaps for nanoparticle delivery.

Project 2: Ras Pathway siRNA in Lung Cancer

Project Investigator: Leaf Huang, Ph.D.
Nanoparticle-based delivery of biologically based therapy to lung cancer, using genetically engineered murine models of lung cancer developed at UNC, is the focus of this Project. Nanoparticles representing PRINT and liposomal formulations will be tested for efficacy of prospective targets.

Project 3: Translational Nanosystems for Improved Lung Cancer Treatment with Small Molecules

Project Investigator: Russell J. Mumper, Ph.D.
This Project will establish the first direct comparison of multiple nanoparticle types that are capable of carrying multiple payloads. Studies will determine efficacy and toxicity of these various approaches against the equivalent of clinical standard of care in sophisticated murine lung cancer models.

Project 4: Compact Micro-Beam Radiation Therapy in Brain Cancer

Project Investigator: Otto Zhou, Ph.D.
Using carbon nanotube-based field emission x-ray technology, a new compact micro-beam radiation therapy source is proposed that will deliver high intensity and spatially distributed radiotherapy to high-grade gliomas and other brain cancers.

Project 5: Digital Breast Tomosynthesis System

Project Investigator: Otto Zhou, Ph.D.
This Project is developing a carbon nanotube-based clinic-ready breast tomosynthesis imaging device. This proposed device will advance early detection and characterization of breast abnormalities, and help to distinguish cancer from benign disease.