Center for Cancer Nanotechnology Excellence and Translation
Sanjiv Sam Gambhir, M.D., Ph.D.
Shan X. Wang, Ph.D.
Project 1: Next-Generation Smart Nanoparticles
Project Investigator: Paul Alivisatos, Ph.D.
The goal of this Project is to engineer, synthesize, characterize, and optimize the next-generation nanoparticle platforms that can potentially be translated clinically to develop nanodiagnostics and imaging agents for the improved management of cancer.
Project 2: Magneto-Nano Diagnostic and Analytical Devices for Cancer
Project Investigator: Shan Wang, Ph.D.
This Project centers on the translational research of devising and applying novel and tunable magnetic nanoparticles (MNP), ultrasensitive magnetic sensor chips, and highly efficient magnetic sorters for cancer biomarkers and cells. The resulting magneto-nano protein chip platform will detect protein biomarkers at attomolar concentrations and will be used for monitoring therapy response in lung cancer and early detection of ovarian cancer. The resulting magnetic sifter and tunable MNP will be used to harvest circulating tumor cells from lung cancer patients or ovarian cancer stem cells at the capture and release efficiencies of >90%.
Project 3: Nanotechnologies for Comprehensive Single Cancer Cell Analysis
Project Investigators: Stephen Quake, D.Phil., and Luke Lee, Ph.D.
This Project plans to develop and apply quantitative, comprehensive single-cell analysis devices for assessing the DNA genome (e.g., single nucleotide polymorphisms, fusions, deletions), RNA expression, protein abundance (cell surface, intracellular, and secretome abundance), and biophysical properties of single cells for the dual purposes of predicting a patientís likely response to EGFR-targeted therapies and for monitoring a patient's acquisition of resistance to EGFR-targeted therapies.
Project 4: Integration of Nano-Molecular Imaging and Nanosensors
Project Investigator: Sanjiv Sam Gambhir, M.D., Ph.D.
The Project will interact with all Projects and Cores due to its integrative nature. It will work with P1 to test gold nanorods for photoacoustic and molecular imaging and perform MRI imaging/validation of self-assembling nanoparticles coming from P1. It will work with P2 to test the magneto-nano sensors with mouse models and work with P3 to test at the single cell level the nanosensors using its mouse models and circulating tumor cells isolated from technologies developed in P2 using patient samples.