Center for Translational Cancer Nanomedicine
Vladimir Torchilin, Ph.D., D.Sc.
Nahum Goldberg, M.D.
Core A: Physico-Chemical Nanocharacterization Core
Core Investigator: Srinivas Sridhar, Ph.D.
This Core will provide the necessary physico-chemical characterization of nanopreparations such as polymeric nanoparticles, lipid nanoparticles, and self-assembling nanosystems prepared in all CCNE Projects. An array of sophisticated microscopic, spectroscopic, and analytical tools are available to study the size, size distribution, stability, surface charge, and drug loading/release from these nanopreparations.
Core B: Imaging Core
Core Investigator: Craig Ferris, Ph.D.
This Core will offer unique capabilities for the visualization of nanopreparations in vivo. The Center currently houses a high-resolution microSPECT/CT and a 7T MR system with a microPET to be installed this year. With extensive experience in onco-based imaging protocols, the imaging core will enable the assessment of kinetics and dynamics of nanopreparations via SPECT, PET, and MR studies.
Core C: Scaling Up and Manufacturing Core
Core Investigator: Tim Coleman, Ph.D.
Nemucore Medical Innovations (NMI) is establishing a first in the Nation cGLP nanomedicine manufacturing facility compliant with Quality by Design (QbD) principles. This Core will focus on converting consortium nanomedicines into target products and defining the critical quality attributes required to manufacture material at a GLP scale. These efforts will prove the NMI facility can become a national resource to advance the promise of nanomedicine.