A major goal of the NCI is to integrate research infrastructures and catalyze cross-disciplinary collaborations to take on large problems in human cancer research and technology development that cannot be addressed by individual investigators. Developing and translating biomedical nanotechnologies for clinical application for cancer and other devastating diseases is one such effort. The Alliance for Nanotechnology in Cancer will integrate the capacities of centers, partnerships, and consortia to increase the pace of technology development and clinical application in the fight against cancer.